We will validate the motion correction algorithms based on flow indices. That is, the registered datasets will be processed to
- create time curves for each of 6 tissue regions,
- create an arterial input function from the automatically determined blood pool curves within the endocardial border,
- subtract off the average of the initial pre-contrast frames and normalize by estimated coil sensitivity differences so that the time curves are proportional to gadolinium concentration, and
- fit the data to a compartment model to obtain myocardial blood flow MBF in ml/g/min (Pack & DiBella, 2010)
The score will be the sum of squared differences of the Myocardial Blood Flow (MBF) index with the registration method, compared to MBF of a pseudo-gold standard obtained from manually drawn contours from experienced analysts.